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SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
7330410C13Rik; A630023E24Rik; im:7427863; SCUBE1; signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB and EGF-like domain-containing protein 1; LOW QUALITY PROTEIN: signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB domain and EGF like domain containing 1; signal peptide, CUB domain, EGF-like 1; signal peptide-CUB domain-EGF-related 1
100 µg
100 µL
100 µL
100 µL
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