|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 154 and 247 of Human 14-3-3 sigma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27147 targets 14-3-3 sigma in IF, IHC (P), and WB applications and shows reactivity with Human, mouse and rat samples.
The PA5-27147 immunogen is synthetic peptide corresponding to a region within amino acids 154 and 247 of Human 14-3-3 sigma.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3 sigma protein; Epithelial cell marker protein 1; Stratifin; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; YWHAS
Gene Aliases: Er; HME1; Mkrn3; Mme1; SFN; YWHAS
Molecular Function: chaperone
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