|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Tested Species reactivity||Chemical|
|Host / Isotype||Goat / IgG|
|Immunogen||8-Hydroxyguanosine - conjugate.|
|Storage buffer||whole serum|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-28031 detects 8-Hydroxyguanosine from various samples.
PA1-28031 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-28031 immunogen is: 8-Hydroxyguanosine - conjugate.
8-hydroxyguanosine (8-OHG) is a marker for measuring the rate of oxidative damage to nucleic acids and lipids. Production of reactive oxygen species (ROS) damage proteins, lipid membranes, and nucleic acids (DNA and RNA), all critical functional components of living cells. The progressive accumulation of unrepaired free radical damage over time is believed to be a major contributor to the aging process and to a variety of age-related chronic diseases. Generation of most free radicals is a 'side effect' of normal metabolic processes, especially mitochondrial production of ROS, including superoxide anion, hydrogen peroxide, and hydroxyl radical, coincident to oxidative metabolism. 8-OHG (marker of oxidative damage to RNA) was found in the cerebral cortex in three of six cases of neuropathologically examined autopsy of subacute sclerosing panencephalitis patients. Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. The concentration of 8-OHG in CSF in Parkinson's disease (PD) patients is approximately three-fold that in controls. The concentration of 8-OHG in CSF decreased significantly with the duration of disease. However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls. [National Center for Biotechnology Information. PubChem Compound Database; CID=65131]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C10H13N5O6
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