|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 40 and 254 of Human ABCE1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30993 targets ABCE1 in immunohistochemistry, Western blot, immunofluorescence, and immunocytochemistry applications and shows reactivity with Human samples.
The PA5-30993 immunogen is recombinant fragment corresponding to a region within amino acids 40 and 254 of Human ABCE1.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2'-5'-oligoadenylate-binding protein; 5'-oligoisoadenylate synthetase-dependent) inhibitor; ABC38; ATP-binding cassette sub-family E member 1; ATP-binding cassette, sub-family E (OABP), member 1; HuHP68; OABP; Ribonuclease 4 inhibitor; ribonuclease L (2'; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; RLI; RNase L inhibitor; RNase L inhibitor 1; RNASEL1; RNASELI; RNS4I
Gene Aliases: ABC38; ABCE1; OABP; OK/SW-cl.40; RLI; RLI1; RNASEL1; RNASELI; RNS4I
UniProt ID: (Human) P61221
Entrez Gene ID: (Human) 6059
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