|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||3-5 µg/10^6 cells|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein derived from the C-terminus of human Acetyl CoA Carboxylase 1 (ACC-1) protein (accession # Q13085, NP_942131), which is identical to chimpanzee. This protein is also 99% similar to Rhesus monkey, 96% similar to pig and bovine and 95% similar to mouse and rat.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACAC; ACACA; ACC-alpha; ACC1; ACCA; Acetyl-CoA carboxylase 1; acetyl-CoA carboxylase-alpha; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase
Gene Aliases: ACAC; ACACA; ACACAD; ACC; ACC1; ACCA
UniProt ID: (Human) Q13085
Entrez Gene ID: (Human) 31
Molecular Function: ligase
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.