|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human AKAP10|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial membrane protein that belongs to the AKAP family. AKAP 10 is a dual specificity protein that binds to both type I and type II regulatory subunits of PKA and anchors them to the plasma membrane or the mitochondria. When anchored to the mitochondria, PKA can phosphorylate and, thus, inactivate the proapoptotic protein Bad. This suggests that AKAP 10 indirectly regulates Bad-induced apoptosis by mediating the mitochondrial attachment of PKA. Additionally, AKAP 10 may facilitate G-protein coupled signal transduction and could act as an adaptor in the assembly of multiprotein complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A kinase (PRKA) anchor protein 10; A kinase anchor protein 10; A-kinase anchor protein 10; A-kinase anchor protein 10, mitochondrial; AKAP-10; AKAP10; D-AKAP-2; Dual specificity A kinase-anchoring protein 2; mitochondrial; mitochondrial A kinase PPKA anchor protein 10; PRKA10; protein kinase A anchoring protein 10; Protein kinase A-anchoring protein 10
Gene Aliases: 1500031L16Rik; AKAP-10; AKAP10; B130049N18Rik; D-AKAP-2; D-AKAP2; PRKA10
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