|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 164 and 475 of ASZ1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALP1; ANKL1; ankyrin repeat; Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; asz1; C7orf7; CT1.19; GASZ; germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein; Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein; Orf3; SAM and basic leucine zipper domain containing 1
Gene Aliases: 4933400N19Rik; Asz1; Gasz; ORF3
UniProt ID: (Mouse) Q8VD46
Entrez Gene ID: (Mouse) 74068
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