|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human PRKAG1/2/3|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non fermentor) kinase family, is a heterotrimeric protein comprise of alpha (63 kDa), beta (30 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non catalytic subunits (although they have been found to interact with the active subunit in liver). AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase. AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-3; 5'-AMP-activated protein kinase, gamma-1 subunit; 5'-AMP-activated protein kinase, gamma-3 subunit; 5-AMP-activated protein kinase, gamma-2 subunit; AMP-activated protein kinase gamma subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit; AMPK gamma-1 chain; AMPK gamma-2 chain; AMPK gamma-3 chain; AMPK gamma1; AMPK gamma2; AMPK gamma3; AMPK subunit gamma-1; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPK- gamma1; AMPK- gamma2; AMPK- gamma3; AMPKg; AMPKG3; H91620p; PRKAG1; PRKAG2; PRKAG3; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Gene Aliases: 2410051C13Rik; AA571379; AAKG; AAKG2; AI854673; Amkg3; AMPKG; AMPKG3; AMPKg3L; AMPKg3S; BB036179; CMH6; H91620p; Prkaac; PRKAG1; PRKAG2; PRKAG3; Prkga1; WPWS
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