|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 2767 and 2843 of Human APC|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30580 targets APC in IF, ICC, and IHC (P) applications and shows reactivity with Human samples.
The PA5-30580 immunogen is synthetic peptide corresponding to a region within amino acids 2767 and 2843 of Human APC.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; BTPS2; Deleted in polyposis 2.5; DP2; DP2.5; DP3; multiple intestinal neoplasia; PPP1R46; Protein APC; protein phosphatase 1; protein phosphatase 1, regulatory subunit 46; regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Aliases: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46
UniProt ID: (Human) P25054
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