|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Bovine, Human, Mouse, Pig, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (19 CFTLYQDEITEREAEP 34) of APG5L protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
ATG5L is a 275 amino acid protein belonging to the ATG5 family and is required for autophagy. It plays an important role in the apoptotic process, within the modified cytoskeleton. It is known to function in autophagy, contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). It conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. Down-regulation of its expression in HeLa cells suppresses cell death and vacuole formation induced by IFN-gamma. It is highly expressed in apoptotic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: APG5; APG5-LIKE; APG5L; apoptosis specific protein; Apoptosis-specific protein; ATG5 autophagy related 5 homolog; Autophagy protein 5; autophagy-related 5; hAPG5
Gene Aliases: 2010107M05Rik; 3110067M24Rik; APG5; APG5-LIKE; APG5L; ASP; ATG5; Atg5l; AW319544; BOS_9664; C88337; hAPG5; Paddy
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