|Western Blot (WB)||4-6 µg/ml|
|Tested Species reactivity||Bovine, Dog, Horse, Human, Marsupial, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (96 KADEGLASLSEDGRSPIS 113) of APH1A protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Gamma-secretase subunit APH1A (APH-1A) is a Notch signaling pathway protein and belongs to the APH-1 family. It is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It is likely a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. It is widely expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6530402N02Rik; anterior pharynx defective 1 homolog A; APH-1; aph-1 homolog A, gamma secretase subunit; APH-1A; Aph-1alpha; APH1A gamma secretase subunit; CGI-78; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; BOS_2946; CGI-78; PSF; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Molecular Function: enzyme modulator
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