|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 472 and 709 of Human APPL1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30502 targets APPL1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-30502 immunogen is recombinant fragment corresponding to a region within amino acids 472 and 709 of Human APPL1.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adapter protein containing PH domain; Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein APPL like; adaptor protein containing pH domain; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AKT2 interactor; APPL; DCC-interacting protein 13-alpha; DIP13 alpha; Dip13-alpha; DIP13alpha; PTB domain and leucine zipper motif 1; signaling adaptor protein DIP13alpha
Gene Aliases: 2900057D21Rik; 7330406P05Rik; AI585782; APPL; APPL1; AW209077; BB022931; C88264; DIP13; DIP13A; DIP13alpha; KIAA1428; MODY14
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