|Western Blot (WB)||0.5-1.5 ug/ml|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (EDGVYEPPDLTP) corresponding to the N-terminus amino acids of PSCD2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine and mouse based on sequence homology.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARF exchange factor; ARF nucleotide binding site opener; ARF nucleotide-binding site opener; ARNO; CLM2; CTC-273B12.8; CTS18; CTS18.1; cytohesin 2; Cytohesin-2; PH, SEC7 and coiled-coil domain-containing protein 2; pleckstrin homology, Sec7 and coiled-coil domains 2; pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2); pleckstrin homology, Sec7 and coiled-coil domains 2-like; pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2); Protein ARNO; PSCD2L; SEC7 homolog B; SEC7L; Sec7p-L; Sec7p-like
Gene Aliases: ARNO; CTS18; CTS18.1; CYTH2; PSCD2; PSCD2L; Sec7; Sec7B; SEC7L; Sec7p-L; Sec7p-like
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