|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 159 and 255 of ATG14|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-34972 targets ATG14 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-34972 immunogen is synthetic peptide corresponding to a region within amino acids 159 and 255 of ATG14.
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG14 is a subunit of a class III phosphatidylinositol (PtdIns) 3-kinase complex that targets the complex to the endoplasmic reticulum, the site of autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATG14 autophagy related 14 homolog; ATG14L; Autophagy-related protein 14-like protein; BARKOR; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; KIAA0831
Gene Aliases: ATG14; ATG14L; BARKOR; KIAA0831
UniProt ID: (Human) Q6ZNE5
Entrez Gene ID: (Human) 22863
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