|ELISA (ELISA)||0.5-1 µg/ml|
|Immunohistochemistry (IHC)||5-15 µg/ml|
|Western Blot (WB)||0.1-0.2 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Recombinant fragment (Human).|
|Purification||Antigen affinity chromatography|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-28007 detects Activin A receptor type IB from human samples.
PA1-28007 has been successfully used in immunohistochemistry, Western blot applications.
The PA1-28007 immunogen is: Recombinant fragment (Human).
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin A receptor type IB; activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRIB; ACVRLK4; ALK-4; ALK4; Serine/threonine-protein kinase receptor R2; SKR2
Gene Aliases: ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2
UniProt ID: (Human) B7Z5W5
Entrez Gene ID: (Human) 91
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.