|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Chicken|
|Host / Isotype||Sheep / IgG|
|Immunogen||Recombinant protein corresponding to the extracellular domain of chicken ALK2.|
|Purification||Ammonium sulfate precipitation|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The TGF-beta superfamily of ligands exerts its biological activity by binding to heteromeric receptor complexes two types (I and II) of the serine/threonine kinases. ALK1, like the other type I receptors, contains a cysteine rich domain with conserved cysteine spacing in the extracellular region and a glycine and serine rich domain preceding the kinase domain. The reduced human ALK1 monomer has a calculated molecular mass of approximately 37.3 kDa. Due to glycoslyation, the recombinant human protein migrates as a 50-55 kDa protein in SDS-PAGE under reducing conditions. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular domains. ALK1 is highly expressed in endothelial cells and other vascular tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activin receptor type I; Activin receptor type-1; ACTRI; ACVR1; ACVRLK2; Type I TGF B receptor
Gene Aliases: ACVR1
UniProt ID: (Chicken) Q90ZK6
Entrez Gene ID: (Chicken) 395246
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