|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 420-471 of human Adducin gamma|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||15mM sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 82 kDa.
Purity is >95% by SDS-PAGE.
Adducins are a family of cytoskeleton proteins encoded by three genes ( alpha, beta and gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and adducins are central in the cortical actin network organization. Adducin alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin alpha and Adducin gamma is ubiquitous in contrast to the restricted expression of Adducin beta. Adducin beta is expressed at high levels in brain andhematopoietic tissues, such as bone marrow in humans, and spleen in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADD3; ADDG; ADDL; Adducin 3; Adducin 3 (gamma); Adducin gamma; Adducin-like protein 70; cytoskeletal protein; Gamma-adducin; potein kinase C binding protein 35H; Protein kinase C-binding protein 35H
Gene Aliases: ADD3; ADDL; AI463285; CPSQ3; R75380
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