|Immunohistochemistry (Paraffin) (IHC (P))||12 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human ADRA2C.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%) Gorilla, Panda, Dog (94%) Mouse, Rat (89%).
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; adrenergic, alpha-2C-, receptor; Adrenoceptor alpha 2C; Alpha 2c; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; Alpha-2c-2 adrenergic receptor; Alpha-2C-adrenergic receptor; Alpha-2C-AR; Alpha-2CAR; Alpha2-AR-C4; Alpha2c; ALPHA2CAR; Alpha2cii-adrenergic receptor
Gene Aliases: ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR
UniProt ID: (Human) P18825
Entrez Gene ID: (Human) 152
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