|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||2.0-4 µg/ml|
|Tested Species reactivity||Bovine, Dog, Horse, Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (211 KHGQRHRAVYDFPQFSTS 228) of Als2Cr2 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
ALS2CR2, a novel anti-apoptotic protein, belongs to the serine/threonine protein kinase STE20 subfamily. Due to the presence of a protein kinase domain with one of the active site residues altered, ALS2CR2 is known as pseudokinase. ALS2CR2 is a component of a complex involved in the activation of a master kinase serine/threonine kinase 11, that regulates cell polarity and energy-generating metabolism and is known to regulate the relocation of this kinase from the nucleus to the cytoplasm. It is essential for G1 cell cycle arrest mediated by this kinase. ALS2CR2 is known to interact with the X chromosome-linked inhibitor of apoptosis protein, and thus enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALS2CR2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; CALS-21; candidate 2; ILP-interacting protein; ILP-interacting protein homolog; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; PAPK; polyploidy associated protein kinase; Polyploidy-associated protein kinase; PRO1038; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: AA792893; ALS2CR2; B830008M19; BOS_2002; CALS-21; D1Ucla2; ILPIP; ILPIPA; PAPK; PRO1038; STRADB; Syradb
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