|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Bovine, Chicken, Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (24 GAQRLLQELVEDKTR 38) of Ambra1 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Ambra1, a WD40 domain containing protein, is a novel activating molecule in Beclin 1-regulated autophagy and plays a role in the development of the nervous system. The protein binds to Beclin 1 and favors Beclin 1/Vps34 interaction. The Ambra1 gene localized on human chromosome 11p11.2, encodes the protein that is highly conserved in vertebrates only and its expression is mostly confined to the neuroepithelium during early neurogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activating molecule in beclin-1-regulated autophagy; activating molecule in Beclin1-regulated autophagy; Activating molecule in BECN1-regulated autophagy protein 1; autophagy/beclin-1 regulator 1; DCAF3; DDB1 and CUL4 associated factor 3; ischemia related factor NYW-1; WD repeat domain 94; WDR94
Gene Aliases: 2310079H06Rik; A130023A14; AA474864; AMBRA1; AV021921; BOS_15131; D030051N19Rik; DCAF3; KIAA1736; mKIAA1736; Nyw1; RCJMB04_3b24; WDR94
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