|Western Blot (WB)||0.5-2 µg/ml|
|Tested Species reactivity||Dog, Human, Mouse, Non-human primate, Rat, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptides corresponding to residues 100-150 of human LSD1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: brain lysate, human brain protein.
LSD1 is a flavin-containing novel nuclear protein having an N-terminal SWIRM domain and a C-terminal FAD-binding motif and an amine oxidase domain. It functions as a transcriptional corepressor and catalyzes the flavin-dependant demethylation of Lys4 of histone3 resulting in the formation of methyl-free lysine and release of formaldehyde. LSD1 has been found to be typically associated with CoREST and histone deacetylases 1 and 4 and participates in the silencing of endogenous neuron-specific genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: amine oxidase (flavin containing) domain 2; AOF2; BRAF35-HDAC complex protein BHC110; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; LSD1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine-specific histone demethylase 1; Lysine-specific histone demethylase 1A; neuroprotective protein 3
Gene Aliases: 1810043O07Rik; AA408884; AOF2; BHC110; CPRF; D4Ertd478e; KDM1; KDM1A; KIAA0601; LSD1; mKIAA0601; RGD1562975; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06
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