|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 653-662 of human amyloid A4 protein precursor.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with rabbit, pig, bovine, guinea pig and chicken based on sequence homology.
In Western blot, this antibody detects a ~120 kDa band in human, mouse and rat brain tissue lysates.
Accumulation of the amyloid- peptide (A ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer and quote;s disease. The amyloid protein precursor (APP) is cleaved by secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for secretase to generate the 4 kDa amyloid- peptide (A ), which is deposited in the brains of all suffers of Alzheimer and quote;s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABPP; AG; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; amyloid A4; amyloid beta (A4) precursor protein; Amyloid beta A4 protein; Amyloid beta A4 protein, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP; Amyloid precursor protein; Amyloidogenic glycoprotein; APP; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; Cerebral vascular amyloid peptide; CVAP; peptidase nexin-II; PN-II; PreA4; protease nexin II; Protease nexin-II; Protease nexin-II, PN-II, APPI, PreA4, A4,; testicular tissue protein Li 2
Gene Aliases: A4; AAA; ABETA; ABPP; AD1; Adap; Ag; APP; APPI; betaApp; CTFgamma; CVAP; E030013M08Rik; PN-II; PN2
Molecular Function: signaling molecule
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