|Western Blot (WB)||1:1000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the C-terminal region of rat APP conjugated to KLH|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine, chicken, human, mouse and non-human primate based on 100% sequence homology.
This antibody is specific for ~115 kDa APP protein. Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen.
A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer and quote;s disease (AD) (Kamenetz et al., 2003). The phosphorylation APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta -amyloid peptide (abeta ) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AAA antibody; ABPP; AG; Alzheimer disease amyloid A4 protein homolog; amyloid A4; Amyloid beta A4 protein; Amyloid precursor protein; Amyloidogenic glycoprotein; APP; Beta-amyloid precursor protein
Gene Aliases: Abeta; App
UniProt ID: (Rat) P08592
Entrez Gene ID: (Rat) 54226
Molecular Function: signaling molecule
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