|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 306 and 692 of Human Artemis|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27112 targets Artemis in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27112 immunogen is recombinant fragment corresponding to a region within amino acids 306 and 692 of Human Artemis.
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA).
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Protein Aliases: A-SCID; DCLREC1C; DNA cross-link repair 1C (PSO2 homolog; DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1C protein; hSNM1C; Protein A-SCID; Protein artemis; PSO2 homolog; RS-SCID; S. cerevisiae); SCIDA; severe combined immunodeficiency; severe combined immunodeficiency, type a (Athabascan); SNM1 homolog C; SNM1-like protein; SNM1C; type a (Athabascan)
Gene Aliases: A-SCID; ARTEMIS; ASCID; DCLRE1C; DCLREC1C; RS-SCID; SCIDA; SNM1C
UniProt ID: (Human) Q96SD1
Entrez Gene ID: (Human) 64421
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