|Flow Cytometry (Flow)||1:50|
|Immunohistochemistry (Frozen) (IHC (F))||1:50|
|Western Blot (WB)||1:50|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human, Rat|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Crude rat liver membrane extracts|
|Storage buffer||PBS with 0.1% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||4° C|
MA1-40244 detects ASGPR from rat and human samples.
MA1-40244 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunofluorescence, and Western blot applications. The typical starting working dilution is 1:10.
The MA1-40244 immunogen is crude rat liver membrane extracts.
Positive control: Rat hepatocytes
Negative control: Rat kidney, pancreas, small intestine, colon
The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral palasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed.The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ASGP-R 1; ASGPR 1; ASGR1; asialoglycoprotein receptor (RHL1); Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1 (hepatic lectin); asialoglycoprotein receptor RHL1; C-type lectin domain family 4 member H1; Hepatic lectin 1; hepatic lectin 1 RHL1; hepatic lectin 1, RHL1; Hepatic lectin H1; HL-1; RHL-1
Gene Aliases: ASGPR; ASGPR1; ASGR; Asgr-1; ASGR1; CLEC4H1; HL-1; RATRHL1; RHL1
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