|Western Blot (WB)||Assay dependent|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Chicken / IgY|
|Immunogen||Recombinant fragment, corresponding to amino acids 1-429 of Human BAF53A.|
|Purification||Antigen affinity chromatography|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-29471 detects BAF53A from mouse, human samples.
PA1-29471 has been successfully used in Western blot applications.
The PA1-29471 immunogen is: Recombinant fragment, corresponding to amino acids 1-429 of Human BAF53A.
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 53 kDa BRG1-associated factor A; actin-like 6; actin-like 6A; Actin-like protein 6A; actin-related protein 4; Actin-related protein Baf53a; ACTL6; Arp4; ARPN-BETA; ArpNbeta; BAF complex 53 kDa subunit; BAF53; BAF53A; BRG1-associated factor 53A; BRG1/brm-associated factor 53A; hArpN beta; INO80 complex subunit K; INO80K; MGC5382
Gene Aliases: 2810432C06Rik; ACTL6; ACTL6A; AI851094; ARP4; ARPN-BETA; BAF53; BAF53A; C79802; INO80K
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