|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human BAK1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27093 targets BAK1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27093 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 44 of Human BAK1.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptosis regulator BAK; BAK; BAK-LIKE; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2L7; CDN1; pro-apoptotic protein BAK
Gene Aliases: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1
UniProt ID: (Human) Q16611
Entrez Gene ID: (Human) 578
Molecular Function: signaling molecule
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