|Immunofluorescence (IF)||20 ug/mL|
|Immunohistochemistry (IHC)||20 ug/ml|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid synthetic peptide near the amino terminus of human BCAR3|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is Hela cell lysate.
PA5-34425 can be used with blocking peptide PEP-1467.
Breast cancer anti-estrogen resistance 3 (BCAR3) was identified in the search for genes involved in the development of estrogen resistance. It contains a putative src homology 2 (SH2) domain and is partly homologous to the cell division cycle protein CDC48. BCAR3 is a binding partner with Cas, an adapter molecule that plays a role in cell proliferation, survival, cell adhesion, and mobility. BCAR3 functions synergistically with Cas to enhance Src activation and promote cell migration, and has been suggested to regulate Cas/Src association, Src kinase activity, and breast cancer adhesion signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AND-34; BCAR3; Breast cancer anti-estrogen resistance 3; Breast cancer anti-estrogen resistance protein 3; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); Novel SH2-containing protein 2; NSP2; p130Cas-binding protein AND-34; SH2 domain-containing protein 3B; SH2D3B
Gene Aliases: AI131758; AND-34; And34; BCAR3; NSP2; SH2D3B; UNQ271/PRO308
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