|Western Blot (WB)||1-10 ug/ml|
|Western Blot (WB)||See 11 publications below|
|Immunocytochemistry (ICC)||See 2 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Tested Species reactivity||Mouse, Rat|
|Published species reactivity||Rat , Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Synthetic peptide corresponding to residues 61-76 of mouse bcl-2.|
|Contains||0.08% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Bcl2 family is a key regulator of apoptosis that functions to either inhibit or promote cell death. Over-expression of members such as Bcl2 and BclxL inhibit the apoptotic process. The Bcl2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with Bcl2 resulting in the enhancement of the anti-apoptotic effect of Bcl2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptosis regulator Bcl-2; AW986256; B cell lymphoma 2 associated oncogene; B-cell leukemia/lymphoma 2; Bcl-2; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik
Gene Aliases: AW986256; Bcl-2; Bcl2; C430015F12Rik; D630044D05Rik; D830018M01Rik
Molecular Function: signaling molecule
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