|Western Blot (WB)||1 - 5 ug/ml|
|Miscellaneous PubMed (MISC)||See 8 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 6 publications below|
|Western Blot (WB)||See 9 publications below|
|Immunohistochemistry (IHC)||See 2 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Mouse, Rat|
|Published species reactivity||Rat , Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Synthetic peptide corresponding to residues 3-14 of the human bcl-xl.|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is human, mouse or rat thymocytes.
Bcl2 family is a key regulator of apoptosis that functions to either inhibit or promote cell death. Over-expression of members such as Bcl2 and BclxL inhibit the apoptotic process. The Bcl2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with Bcl2 resulting in the enhancement of the anti-apoptotic effect of Bcl2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; bcl-2 L1; Bcl-2-like protein 1; Bcl-X; BCL-XL/S; bcl-xS; Bcl2-L-1; BCL2L; BCLX; DKFZp781P2092
Gene Aliases: Bcl(X)L; bcl-X; Bcl-XL; bcl2-L-1; Bcl2l; Bcl2l1; BclX; Blc2l
Molecular Function: signaling molecule
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