|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fusion protein corresponding to residues 171-356 of human BLNK.|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage conditions||4° C, do not freeze|
SLP65 / BLNK (SH2 domain-containing leukocyte-specific phosphoprotein of 65 kDa; B cell linker protein), also known as BASH, is an adaptor protein that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). Phosphorylated by Syk tyrosine kinase, SLP65 serves as a scaffold for Btk tyrosine kinase, Vav1 guanine nucleotide exchange factor, phospholipase C gamma2, as well as Grb2 and Nck adaptor proteins; thus represents a central linker protein that bridges the BCR-associated kinases with a multitude of signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; BASH; BLNK; BLNK-s; Cytoplasmic adapter protein; Ly57; Lymphocyte antigen 57; MGC111051; Slp-65; SLP65; Src homology 2 domain-containing leukocyte protein of 65 kDa
Gene Aliases: BASH; Bca; Blnk; Ly-57; Ly57; Lyw-57; SLP-65; Slp65
UniProt ID: (Mouse) Q9QUN3
Entrez Gene ID: (Mouse) 17060
Molecular Function: signaling molecule
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