|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1:200-1:500|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to internal residues 200-300 of the human beclin 2. [NCBI# XP_945075]|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 30% glycerol|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Suggested positive control: 293 whole cell lysate, HEK293 kidney cell lysates and MCC827 lung cell lysates.
Does not appear to work with A431 lysates.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl-2; beclin 1, autophagy related, pseudogene 1; Beclin-1 autophagy-related pseudogene 1; Beclin-1-like protein 1; Beclin-2
Gene Aliases: BECN1L1; BECN1P1; BECN2
UniProt ID: (Human) A8MW95
Entrez Gene ID: (Human) 441925
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