|Immunohistochemistry (Frozen) (IHC (F))||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Partial recombinant protein containing residues KDHMDPYWALENRDEAHS, coupled to KLH.|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody does not react with rat samples.
Suggested positive control: Pig RPE (retinal Pigment Epithelium) whole cell extract.
Best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). It is inherited and has an early onset. Bestrophin is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophins function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARB; BEST; Best disease; Best1V1Delta2; Bestrophin-1; BMD; TU15B; Vitelliform macular dystrophy protein 2; VMD2
Gene Aliases: ARB; BEST; BEST1; BMD; RP50; TU15B; VMD2
UniProt ID: (Human) O76090
Entrez Gene ID: (Human) 7439
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