|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Synthetic peptides corresponding to the N-terminal, internal, and C-terminal regions of human B1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.
BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bax inhibitor 1; Bax inhibitor-1; BAXI1; BI-1; TEGT; testis enhanced gene transcript; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6
Gene Aliases: 5031406P05Rik; Ab1-011; Ac1-149; BAXI1; BI-1; BI1; Cc1-27; TEGT; TMBIM6
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