|Immunoprecipitation (IP)||1-4 µg/mg of lysate|
|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to a portion of human Bloom Syndrome encoded within exon 2.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate/tris phosphate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-26718 detects Blooms Syndrome Protein Blm from human samples.
PA1-26718 has been successfully used in Western blot procedures.
The PA1-26718 immunogen is a synthetic peptide corresponding to a portion of human Bloom Syndrome encoded within exon 2.
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BLM; Bloom syndrome protein; Bloom syndrome, RecQ helicase-like; DNA helicase, RecQ-like type 2; RecQ protein-like 3; RecQ2
Gene Aliases: BLM; BS; RECQ2; RECQL2; RECQL3
UniProt ID: (Human) P54132
Entrez Gene ID: (Human) 641
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