|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Western Blot (WB)||See 4 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide derived from the mid region of the human Bim-1 protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B lymphoma Mo-MLV insertion region 1 homolog; BMI1; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; murine leukemia viral (bmi-1) oncogene homolog; PCGF4; polycomb group protein Bmi1; polycomb group RING finger protein 4; ring finger protein 51; RNF51
Gene Aliases: flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
Entrez Gene ID: (Human) 648
Molecular Function: ubiquitin-protein ligase
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