|Western Blot (WB)||1:1000|
|Tested Species reactivity||Hamster, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms.Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C3/C5 convertase; CO2; Complement C2; complement component C2
Gene Aliases: ARMD14; C2; CO2
UniProt ID: (Human) P06681
Entrez Gene ID: (Human) 717
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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