|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment contains a sequence corresponding to a region within amino acids 11 and 244 of CACNB4|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-34820 targets CACNB4 in WB applications and shows reactivity with Human samples.
The PA5-34820 immunogen is recombinant fragment contains a sequence corresponding to a region within amino acids 11 and 244 of CACNB4.
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy . Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CAB4; CACNLB4; calcium channel beta-4 subunit; Calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit; dihydropyridine-sensitive L-type; dihydropyridine-sensitive L-type, calcium channel beta-4 subunit; EA5; EIG9; EJM; EJM4; EJM6; Voltage-dependent L-type calcium channel subunit beta-4
Gene Aliases: CAB4; CACNB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6
UniProt ID: (Human) O00305
Entrez Gene ID: (Human) 785
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