|Flow Cytometry (Flow)||3-5 µg/10^6 cells|
|Immunocytochemistry (ICC)||2 µg/mL|
|Immunofluorescence (IF)||2 µg/mL|
|Immunoprecipitation (IP)||5 µg|
|Western Blot (WB)||1-3 µg/mL|
|Western Blot (WB)||See 7 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the N-terminal region of the human and predicted chimpanzee CAP43 proteins, which differs from predicted bovine by one amino acid change and from mouse and rat by two amino acid changes|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth and differentiation. Its defect causes Charcot-Marie-Tooth disease type 4D (CMT4D) that is characterized by reduced nerve conduction velocities, segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes and hollow feet. NDRG1 plays a growth inhibitory role and serves as a marker of differentiation. It is expressed in placental membranes, prostate, kidney, small intestine, ovary tissues, colon and the cells that border the lumen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAP43; CMT4D; Differentiation-related gene 1 protein; DRG-1; DRG1; GC4; HMSNL; N-myc downstream regulated 1; N-myc downstream-regulated gene 1 protein; NDR1; Nickel-specific induction protein Cap43; NMSL; Protein Ndr1; Protein NDRG1; protein regulated by oxygen-1; PROXY1; Reducing agents and tunicamycin-responsive protein; RIT42; RTP; TARG1; TDD5; tunicamycin-responsive protein
Gene Aliases: CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NDRG1; Ndrl; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
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