|Immunocytochemistry (ICC)||10 µg/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Western Blot (WB)||5-10 ug/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to 14 amino acids at the C-terminus of human CARD10.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is EL4 cell lysate.
PA5-19997 can be used with blocking peptide PEP-0119.
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10. This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kappa-B. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the Ikappa-K complex, demonstrating its importance in the regulation of NF-kappa-B transcription factor activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl10 binding protein and activator of NFKB; Bcl10-interacting MAGUK protein 1; Bimp1; BIMP1, CARMA3; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; caspase recruitment domain family, member 10; Caspase recruitment domain-containing protein 10
Gene Aliases: AI449026; BIMP1; CARD10; CARMA3
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