|Immunohistochemistry (IHC)||5 ug/mL|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid synthetic peptide near the amino terminus of human CARMA3|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human kidney tissue.
PA5-34364 can be used with blocking peptide PEP-1407.
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl10 binding protein and activator of NFKB; BIMP1; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; CARD10; Carma 3; CARMA3; Caspase recruitment domain family member 10; caspase recruitment domain family, member 10; Caspase recruitment domain-containing protein 10
Gene Aliases: BIMP1; CARD10; CARMA3
UniProt ID: (Human) Q9BWT7
Entrez Gene ID: (Human) 29775
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