|Western Blot (WB)||0.3-1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (CKERAEEIYPIKERN) corresponding to the internal amino acids of CASP4|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, feline and mouse based on sequence homology.
This gene encodes a protein that is a member of the cysteine-aspartic acid protease family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; ICE and Ced-3 homolog 2; ICE(rel)-II; ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; protease ICH-2; Protease TX; TX
Gene Aliases: CASP4; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1; Mih1/TX; TX
UniProt ID: (Human) P49662
Entrez Gene ID: (Human) 837
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