|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||5 ug/mL|
|Immunohistochemistry (IHC)||5 ug/mL|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid synthetic peptide near the carboxy terminus of human CCP110|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human colon tissue lysate.
PA5-34380 can be used with blocking peptide PEP-1423.
CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs); disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCP110; Centriolar coiled coil protein 110; centriolar coiled coil protein 110kDa; centriolar coiled-coil protein 110kDa; Centriolar coiled-coil protein of 110 kDa; centrosomal protein CP110; Centrosomal protein of 110 kDa; CEP1; CEP110; CNTRL; CP110; FAN
Gene Aliases: 6330503K22Rik; AA415922; AI427129; AW557948; CCP110; CEP110; CP110; KIAA0419; RGD1310509
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