|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a portion of human CCR3 protein.|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Suggested positive control: antigen standard for CCR3 (transient overexpression lysate), Daudi.
Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR3 (eotaxin receptor), is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin, including RANTES, monocyte chemotactic protein (MCP)-2, MCP-3, and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, and inhibited infection by these isolates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: b-chemokine receptor; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; CD193; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; CKR3; CMKBR3; eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; Macrophage inflammatory protein 1-alpha receptor-like 2; MGC102841; MIP-1 alpha RL2; MIP-1 alphaRL2; Probable C-C chemokine receptor type 3
Gene Aliases: CC-CKR-3; CC-CKR3; CCR3; CD193; CKR3; Cmkbr1l2; CMKBR3
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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