|Immunohistochemistry (Paraffin) (IHC (P))||1:300|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to residues Y Q V S S P I Y D I N Y Y T S E P C Q K I N V K Q I A A of human.|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M potassium phosphate, pH 7.2, with 0.14M NaCl, 1mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-21627 detects CCR5 in human samples.
PA1-21627 has been successfully used in ELISA, immunocytochemistry, immunohistochemistry (FFPE) and Western blot procedures.
The PA1-21627 immunogen is a synthetic peptide corresponding to residues Y Q V S S P I Y D I N Y Y T S E P C Q K I N V K Q I A A of human.
Receptors for the C-C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. The HIV receptor is composed of two molecules, the CD4 binding receptor and a co-receptor. The chemokine receptor CCR 5 is one of the co-receptors used by primary isolates of HIV-1. Extracellular domains of CCR 5 are important for HIV entry into the target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; CHEMR13; CMKBR5; HIV-1 fusion coreceptor
Gene Aliases: CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
UniProt ID: (Human) P51681
Entrez Gene ID: (Human) 1234
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor
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