|Flow Cytometry (Flow)||0.5 ug/10^6 cells|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Immunogen||Rat monoclonal antibody raised against inflamed mouse skin.|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage conditions||4° C, do not freeze|
MA5-17946 targets CD105/Endoglin in FACS, IHC, IP, and WB applications and shows reactivity with Mouse samples.
The MA5-17946 immunogen is rat monoclonal antibody raised against inflamed mouse skin.
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFßR-2 as a receptor for TGFß-1 and TGFß-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFß-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD105; CD105 antigen; Cell surface MJ7/18 antigen; END; Endoglin; ENG; HHT1; ORW; ORW1; transmembrane glycoprotein
Gene Aliases: AI528660; AI662476; CD105; Edg; Endo; Eng; S-endoglin
UniProt ID: (Mouse) Q63961
Entrez Gene ID: (Mouse) 13805
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