|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
|Immunohistochemistry (IHC)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein encoding aa 26-176 of human CD105|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
PA5-16895 targets CD106 in IHC (P) and ICC/IF applications and shows reactivity with Human samples.
The PA5-16895 immunogen is recombinant protein encoding aa 26-176 of human CD105.
CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-beta1 and beta3 with high affinity but not TGF-beta2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD105; CD105 antigen; END; Endoglin; ENG; HHT1; ORW; ORW1
Gene Aliases: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
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