|Flow Cytometry (Flow)||1:2|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:20|
|Western Blot (WB)||1:100-1:500|
|Immunohistochemistry (IHC)||See 8 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recombinant protein encoding the external domain of human CD21|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-11417 targets CD21 in WB, FACS and IHC (P) applications and shows reactivity with Human samples. This antibody is not suitable for Raji cell lysates or mouse BAF-3 cell lysates in Western blot analysis.
The MA5-11417 immunogen is recombinant protein encoding the external domain of human CD21.
CD21, also known as CR2, C3d receptor and EBV receptor), is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD21; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; Complement receptor type 2; Cr2; EBV receptor; Epstein-Barr virus receptor
Gene Aliases: C3DR; CD21; CR; CR2; CVID7; SLEB9
UniProt ID: (Human) P20023
Entrez Gene ID: (Human) 1380
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