|Flow Cytometry (Flow)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2b, kappa|
|Immunogen||Spleen cells of a patient with hairy cell leukemia|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-13567 targets CD37 in FACS, IF, and IHC (F) applications and shows reactivity with Human samples.
The MA5-13567 immunogen is spleen cells of a patient with hairy cell leukemia.
CD37, a tetraspan transmembrane protein, is strongly expressed on normal and neoplastic mature (sIg+) B lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD37 is absent from platelets, erythrocytes. It associates with other tetraspan transmembrane proteins and MHC class II molecules to form a large complexes at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin lymphoma (B-NHL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD37; CD37 antigen; cell differentiation antigen 37; GP52-40; Leukocyte antigen CD37; leukocyte surface antigen CD37; Tetraspanin-26; Tspan-26; TSPAN26
Gene Aliases: CD37; GP52-40; TSPAN26
UniProt ID: (Human) P11049
Entrez Gene ID: (Human) 951
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