|Flow Cytometry (Flow)||Neat|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||113 Amino acid synthetic peptide corresponding to the cytoplasmic domain of murine zeta TCR subunit|
|Storage buffer||PBS, pH 7.2, with 1% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred, store in dark|
Membrane permeabilization is required for flow cytometry applications. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD247 antigen; CD247 antigen, zeta subunit; CD3 antigen, zeta polypeptide; CD3-ZETA; CD3-zeta/eta; CD3H; CD3Q; CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 eta chain; T-cell receptor T3 zeta chain; T-cell surface glycoprotein CD3 zeta chain; T3Z; TCR zeta chain; TCRZ
Gene Aliases: 4930549J05Rik; A430104F18Rik; AW552088; Cd3; Cd3-eta; CD3-ZETA; CD3H; CD3Q; CD3Z; Cd3zeta; IMD25; T3Z; Tcrk; TCRZ
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